Congenital insensitivity to pain: Review with dental implications

Congenital Insensitivity to Pain with Anhidrosis in an Iranian Patient

Congenital insensitivity to pain with anhidrosis is a rare disease of the nervous system which causes one to lose his/her feeling of pain. The disease is subtype four of hereditary sensory and autonomic neuropathy (HSAN IV) that results from NTRK1 gene defect. Direct sequencing was performed to screen NTRK1 for mutations. The result revealed a homozygous deletion of adenine on intron 14 that ma...

[Congenital insensitivity to pain with anhydrosis].

Congenital insensitivity to pain with anhydrosis (CIPA) is a rare genetic disorder characterized by inability to feel pain and temperature, and decreased or absent sweating. Familiarity to this condition is important to avoid misdiagnosing it with leprosy and other peripheral nerve diseases. An inability to feel pain may lead to repeated self-trauma (tongue, lips and finger tips) ultimately lea...

Norrbottnian congenital insensitivity to pain.

Congenital insensitivity to pain is a rare hereditary neuropathy. We present patients from a large family in Norrbotten, Sweden with a mutation in the nerve growth factor beta gene (NGFbeta). Using a model of recessive inheritance, we identified an 8.3-Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family. Analysis of candidate genes in the disease-critical regio...

Topical review Congenital insensitivity to pain: an update

Elna M. Nagasako, Anne Louise Oaklander, Robert H. Dworkin* Washington University School of Medicine, St. Louis, MO, USA Nerve Injury Unit, Departments of Anesthesiology, Neurology, and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 604, Rochester, ...

congenital insensitivity to pain with anhidrosis (cipa): a case report